Hoatlin Lab

Home        Projects        Team        Papers        Contact Us        Protocols        Collaborations        News        Reagent Requests        secret back door        Hoatlin Lab Twitter       

Lab News For news, follow the Hoatlin lab Twitter Our laboratory is interested in understanding the molecular function of the Fanconi anemia (FA) protein network in context with other proteins that regulate or influence genomic stability. Fanconi anemia is a rare genetic disease that is typically associated with developmental abnormalities, bone marrow failure and increased risk of cancer. Because the majority of the FA proteins are unique with no significant homologies, we expect the results of our studies to shed new light on fundamental mechanisms that control the integrity of the human genome and influence cancer susceptibility. The FA pathway is part of a network of proteins that contains BRCA2 and two other recently identified FA genes (FANCN and FANCJ) that influence breast cancer susceptibility. Ultimately, insights into the mechanism of the FA/BRCA network of proteins will lead to an understanding of the underlying molecular defect in FA and may lead to more effective avenues of treatment for this devastating pediatric disease and cancer. We work in Portland, Oregon at OHSU, in the Department of Biochemistry & Molecular Biology and the OHSU Knight Cancer Institute. Bio for Maureen Hoatlin Maureen Hoatlin is an Associate Professor of Biochemistry & Molecular Biology, and Molecular & Medical Genetics at Oregon Health & Science University (OHSU). After earning a B.S. degree in Chemistry from Old Dominion University, she was a project chemist at SRI International in Menlo Park, CA for two years, followed by six years as a research associate at Genentech, Inc. She received a Ph.D. at Oregon Health & Science University for graduate work focusing on the role of retroviruses in pathogenesis and hematopoietic cancers. She joined the faculty in Hematology & Medical Oncology at OHSU in 1993, and was a Visiting Scientist & Professor in the Department of Genetics at the Free University and Medical Center of Amsterdam in 1998 and in 2002. Dr. Hoatlin’s research is focused on identifying and analyzing the function of the proteins in the Fanconi Anemia/Breast Cancer (FA/BRCA) cancer susceptibility pathway. Her work has contributed to the discovery and characterization of ten novel human genes, many with critical but poorly understood roles in hematopoiesis, cancer susceptibility (AML and other cancers), and resistance to certain commonly-used chemotherapeutic drugs. Dr. Hoatlin’s lab pioneered a cell-free approach to analyze the function of the FA/BRCA pathway and recently received a patent for a novel small molecule inhibitor screen for identification of FA/BRCA pathway inhibitors and potential chemosensitizing compounds. Dr. Hoatlin has recently completed an MBA with a specialty on international business in Asia, as well a specialized UCSF course (ACDRS) on the drug development pipeline that focuses on preparation for future developments and changes in the global pharmaceutical sector. Dr. Hoatlin is a member of the strategic planning leadership for OHSU’s School of Medicine, the Hematologic Malignancies Program, advisory board member of the Oregon Translational Research and Development Institute, and founding co-chair of the OHSU Rare Disease Consortium. Dr. Hoatlin is interested in developing industry-academic partnerships aimed at using rare disease research to de-risk drug development. Teaching Links Our lab's Fanconi Anemia antibodies are available from Novus Biologicals and by Millipore. PMCB Conjoint Class 2018-2019 Genetic Mechanisms Class (CON662) Med Students Fundamentals Biochemistry Seminar Series Biochemistry Seminar Series and Combined Series Working Draft Classes of the past CONJ606/PMCB 2017-2018 Advanced Topics in Molecular Biology(BMB625) Advanced Topics in Cancer Biology (CANB 610) OHSU DNA Replication, Recombination and Repair (R3) Club. Basic Wiki/OWW Links Help Overview How to join Using OpenWetWare Guidelines for editing OpenWetWare <wikionly> Recent changes List of abbreviations: N This edit created a new page (also see list of new pages) m This is a minor edit b This edit was performed by a bot (±123) The page size changed by this number of bytes 29 April 2024 N    08:30  UA Biophysics:Protocols:Calcein8 ESP‎ diffhist +1,771‎ Elizabeth Suesca talk contribs (Created page with "'''Calceina: 800 mOsM, 50 mM, 50 ml, pH 7.4 ''' ==Materiales: == * Probeta 100 ml * 30 ml de NaOH (1M) * HCl (1M) * NaCl * 1.5564 g de calceina * 40 ml Buffer H: ** 5 ml de EDTA 0.2 mM (Para que quede a 0.01 mM en la solución final) ** HEPES 238.3 mg (para que quede a 10 mM en la solución final). ==Procedimiento: == # En la probeta medir 10 ml de NaOH 1M y colocar agitador # Disolver en el NaOH 1.5564 g de calceina (50 mM o 50 mOsM) # Agregar 200 mM de NaCl (...")      07:57  UA Biophysics:Protocols:Calcein ESP‎ diffhist +1‎ Elizabeth Suesca talk contribs 28 April 2024      18:59  CHEM-ENG590E:Wiki Textbook‎‎ 2 changes history −1‎ [Nmhatre‎ (2×)]       18:59 (cur | prev) −17‎ Nmhatre talk contribs (→‎Chapter 4 - Flow Control and Mixing)       18:59 (cur | prev) +16‎ Nmhatre talk contribs (→‎Chapter 4 - Flow Control and Mixing)      18:56  Microfluidic Gradient Generators - Greg Schneider‎‎ 20 changes history +588‎ [Nmhatre‎ (20×)]       18:56 (cur | prev) −377‎ Nmhatre talk contribs (→‎Mathematical Model)       18:45 (cur | prev) +245‎ Nmhatre talk contribs (→‎Mathematical Model)       18:37 (cur | prev) +2‎ Nmhatre talk contribs (→‎Mathematical Model) Tag: Manual revert       18:36 (cur | prev) −2‎ Nmhatre talk contribs (→‎Mathematical Model)       18:36 (cur | prev) 0‎ Nmhatre talk contribs (→‎Varying Flowrates and Asymmetrical Geometry)       18:36 (cur | prev) +6‎ Nmhatre talk contribs (→‎Varying Flowrates and Asymmetrical Geometry)       18:35 (cur | prev) −35‎ Nmhatre talk contribs (→‎Microfluidic Gradients Background) Tag: Manual revert       18:32 (cur | prev) +35‎ Nmhatre talk contribs (→‎Microfluidic Gradients Background)       18:29 (cur | prev) −1‎ Nmhatre talk contribs (→‎Induced Charge Electro-Osmosis (ICEO))       18:28 (cur | prev) −1‎ Nmhatre talk contribs (→‎Induced Charge Electro-Osmosis (ICEO))       18:28 (cur | prev) −1‎ Nmhatre talk contribs (→‎Varying Flowrates and Asymmetrical Geometry)       18:28 (cur | prev) −1‎ Nmhatre talk contribs (→‎Mathematical Model)       18:27 (cur | prev) −1‎ Nmhatre talk contribs (→‎Methods For Creating Non-linear Gradients)       18:27 (cur | prev) −1‎ Nmhatre talk contribs (→‎Modified Gradient Tree with Varying Horizontal Channel Width)       18:26 (cur | prev) −1‎ Nmhatre talk contribs (→‎Modified Gradient Tree with Varying Horizontal Channel Width)       18:26 (cur | prev) +1‎ Nmhatre talk contribs (→‎Modified Gradient Tree with Varying Horizontal Channel Width)       18:26 (cur | prev) +6‎ Nmhatre talk contribs (→‎Modified Gradient Tree with Varying Horizontal Channel Width)       18:25 (cur | prev) +8‎ Nmhatre talk contribs (→‎Modified Gradient Tree with Varying Horizontal Channel Width)       18:22 (cur | prev) +8‎ Nmhatre talk contribs (→‎Uses)       18:21 (cur | prev) +698‎ Nmhatre talk contribs (→‎Uses)      18:55  (Upload log)‎ [CarterPaul‎; Nmhatre‎ (2×)]       18:55 Nmhatre talk contribs uploaded File:Nonlineargradientmodel.jpeg ‎       18:24 Nmhatre talk contribs uploaded File:Nonlinear Gradient Tree with Varying Horizontal Channel Width.png ‎       18:18 CarterPaul talk contribs uploaded File:NIL2.png ‎      18:39  Nanoimprint Lithography (NIL) - Carter Paul‎‎ 17 changes history +1,389‎ [CarterPaul‎ (17×)]       18:39 (cur | prev) +1‎ CarterPaul talk contribs       18:38 (cur | prev) +12‎ CarterPaul talk contribs       18:38 (cur | prev) +8‎ CarterPaul talk contribs (→‎Ultraviolet (UV) NIL and Machining Mechanism)       18:35 (cur | prev) −6‎ CarterPaul talk contribs (→‎T-NIL Resist)       18:29 (cur | prev) +1‎ CarterPaul talk contribs       18:29 (cur | prev) +11‎ CarterPaul talk contribs       18:28 (cur | prev) +1‎ CarterPaul talk contribs       18:28 (cur | prev) 0‎ CarterPaul talk contribs (→‎Roll-to-roll T-NIL)       18:27 (cur | prev) 0‎ CarterPaul talk contribs (→‎Roll-to-roll T-NIL)       18:27 (cur | prev) +52‎ CarterPaul talk contribs       18:25 (cur | prev) −4‎ CarterPaul talk contribs (→‎Roll-to-to-roll T-NIL)       18:25 (cur | prev) +203‎ CarterPaul talk contribs       18:19 (cur | prev) +2‎ CarterPaul talk contribs       18:16 (cur | prev) −3‎ CarterPaul talk contribs (→‎Thermal NIL Process)       18:14 (cur | prev) −4‎ CarterPaul talk contribs       18:12 (cur | prev) +1,115‎ CarterPaul talk contribs (→‎Thermal NIL Process)       17:58 (cur | prev) 0‎ CarterPaul talk contribs (→‎Roll-to-roll NIL Fabrication Example)      18:36  Capillary Electrophoresis - Andrew Maloney, Tim Towner, Camryn Payne‎ diffhist −5‎ Camrynpayne talk contribs (→‎Background)      18:01  Multilayer Paper Microfluidics - Madyson Redder‎‎ 5 changes history +94‎ [Mredder‎ (5×)]       18:01 (cur | prev) +4‎ Mredder talk contribs (→‎Origami Folding)       18:01 (cur | prev) −2‎ Mredder talk contribs (→‎Origami Folding)       17:59 (cur | prev) +3‎ Mredder talk contribs (→‎Origami Folding)       17:59 (cur | prev) +46‎ Mredder talk contribs (→‎Origami Folding)       17:58 (cur | prev) +43‎ Mredder talk contribs </wikionly>